氨基胍盐酸盐, 二胺氧化酶和一氧化氮合酶抑制剂
Aminoguanidine Hydrochloride
CAS: 1937-19-5;16139-18-7
Molecular Formula: CH7ClN4
氨基胍盐酸盐, 二胺氧化酶和一氧化氮合酶抑制剂 - Names and Identifiers
| Name | Aminoguanidine Hydrochloride |
| Synonyms | amino-guanidinhydrochloride carbazamidine hydrochloride Aminoguanidine Hydrochloride Aminoguanadine hydrochloride 2-aminoguanidine hydrochloride carbazamidine monohydrochloride hydrazinecarboximidamidehydrochloride (diaminomethylidene)hydrazinium chloride Metformin Impurity 15(Aminoguanidine hydrochloride) |
| CAS | 1937-19-5 16139-18-7 |
| EINECS | 217-707-7 |
| InChI | InChI=1/CH6N4.ClH/c2-1(3)5-4;/h4H2,(H4,2,3,5);1H |
氨基胍盐酸盐, 二胺氧化酶和一氧化氮合酶抑制剂 - Physico-chemical Properties
| Molecular Formula | CH7ClN4 |
| Molar Mass | 110.54608 |
| Melting Point | 162-166°C(lit.) |
| Boling Point | 261.4°C at 760 mmHg |
| Flash Point | 111.9°C |
| Water Solubility | 506.7g/L at 20℃ |
| Solubility | Completely soluble in water |
| Vapor Presure | 0Pa at 25℃ |
| Appearance | White to white-like crystals |
| Color | White to off-white |
| Merck | 13,440 |
| BRN | 3909606 |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| MDL | MFCD00039074 |
| In vivo study | Aminoguanidine can improve neonatal hypoxic-ischemic brain damage, and the time distribution of NO is related to the neuroprotective effect of aminoguanidine. AG exerts its neuroprotective effect by inhibiting NO produced by iNOS during post-hypoxia reoxygenation. The Half-Life of Aminoguanidine in the body is about 6-8 hours, and about 4.4 hours in people with normal renal function. Minoguanidine is also an inhibitor of the formation of advanced glycation end products. Treatment of adult rats with BSA modified by advanced glycation end products increased their cerebral infarct size, while Aminoguanidine attenuated this effect. |
氨基胍盐酸盐, 二胺氧化酶和一氧化氮合酶抑制剂 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | ME8430000 |
| FLUKA BRAND F CODES | 10-21 |
| HS Code | 29280000 |
氨基胍盐酸盐, 二胺氧化酶和一氧化氮合酶抑制剂 - Reference
| Reference Show more | 1. [IF=6.057] Ying Wang et al."Enhancement effect of p-iodophenol on gold nanoparticle-catalyzed chemiluminescence and its applications in detection of thiols and guanidine."Talanta. 2018 May;182:523 2. [IF=2.776] Wenlu Li et al."Edaravone Protected Human Brain Microvascular Endothelial Cells from Methylglyoxal-Induced Injury by Inhibiting AGEs/RAGE/Oxidative Stress."Plos One. 2013 Sep;8(9):e76025 3. [IF=5.275] Remah Sobhy et al."The noncovalent conjugations of bovine serum albumin with three structurally different phytosterols exerted antiglycation effects: A study with AGEs-inhibition, multispectral, and docking investigations."Bioorg Chem. 2020 Jan;94:103478 4. [IF=6.576] Yingchun Jin et al."Characteristics of Mulberry Leaf Powder Enriched With γ-Aminobutyric Acid and Its Antioxidant Capacity as a Potential Functional Food Ingredient."Frontiers in Nutrition. 2022; 9: 900718 |
氨基胍盐酸盐, 二胺氧化酶和一氧化氮合酶抑制剂 - Reference Information
| LogP | -3.55 at 20℃ |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Application | Aminoguanidine hydrochloride is a pharmaceutical intermediate and organic synthesis intermediate, which can be prepared from aminoguanidine carbonate and can be used in the preparation of daidzein derivatives and laboratory organic synthesis process. |
| preparation | preparation of aminoguanidine hydrochloride: weigh 9g of aminoguanidine carbonate and place it in a 250ml three-mouth flask, add 20ml of anhydrous ethanol, the solid is insoluble in anhydrous ethanol to form a suspension, add a mixture of 6ml of 30% concentrated hydrochloric acid and 10ml of anhydrous ethanol dropwise under room temperature stirring, until no bubbles are generated, and continue stirring and reaction at room temperature for 1 hour. Heat the resulting suspension to completely dissolve the solid, naturally drop to room temperature, move to the refrigerator, and leave it overnight to obtain a white rod-shaped crystal with a melting point of 166-167°C. |
| Biological activity | Aminoguanidine (Pimagedine, Guanyl hydrazine, Hydrazinecarboximidamide, Imino semicarbazide, Monoaminoguanidine) is an inhibitor of diamine oxidase and nitric oxide synthase. It reduces the level of advanced glycation end products (AGEs) by interacting with 3-deoxyglucosone. |
| Target | Value |
| category | toxic substances |
| toxicity classification | poisoning |
| acute toxicity | subcutaneous-rat LDL0: 2984 mg/kg |
| flammability hazard characteristics | combustible; combustion produces toxic nitrogen oxides and hydrogen chloride smoke |
| storage and transportation characteristics | warehouse ventilation and low temperature drying |
| fire extinguishing agent | dry powder, foam, sand, carbon dioxide, mist water |
Last Update：2024-04-09 19:05:10
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